LaCava Research Wiki

Initiated September 2017

1. Conjugation of new anti-ORF1p antibodies and Dynabeads_Dec 2 2019

Lars10th January 2020 at 11:10am

AIM/HYPOTHESIS

A new batch of antibodies arrived that will be used for IPs, and hence needed to be conjugated to Dynabeads.

MATERIALS

NameCompanyCat. nr.Date received/madeComments
Dynabeads M270 EpoxyInvitrogen Dynal143.02D
a-ORF1p absAbmart5310-1-4/4H1received Nov 18 2019Custom synthesized, identical to the Milipore Sigma product: anti-ORF1p 4H1

METHODS

Conjugation was done according to Conjugation of antibody Dynabeads. Used volumes:

* 103ul antibody 
* 100ul 3M ~AmSO4
* 97ul 0.1M ~NaPO4, pH 7.4

RESULTS

Concentrations of antibody mix:

Before desalting 1.5 mg/ml
After desalting 1.45 mg/ml

See for validation Testing of new anti-ORF1p beads_Dec 4 2019

DISCUSSION

-