LaCava Research Wiki

Initiated September 2017

3xFLAG-tagged Transcription Factor Constructs & Cell Lines

leilala10th January 2020 at 11:13am

TF 3xFLAG Flp-In constructs


(alphabetical)

NFKB1-3xFLAG –> cell line made

STAT3-3xFLAG —> cell line made

SMAD4-3xFLAG —> cell line made

TP53-3xFLAG —> amino acid substitutions, needs MISO (in progress)

3xFLAG cell lines made

STAT3-3xFLAG —> Leaky expression. Does not appear to purify a complex BUT needs to be tried under TP53 sonication conditions (25x2s) and/or w/ glutaraldehyde. We can compare performance of CDI anti-STAT3 to anti-FLAG now (done, see here )

SMAD4-3xFLAG —> Expression looks ok. Other results pending.