LaCava Research Wiki

Initiated September 2017

ORF1p LFQ screen N2102Ep α-ORF1p 4H1

jlacava13th January 2022 at 3:14pm
  • 24 multi-channel prescreen in duplicate
  • 24 manual prescreen in duplicate
  • 4x6 multi-channel screen

4x6 manual –> I thought we did this but I don't currently find the data for it. This data seems to be the "no treatment" group for the ROME screen - ORF1p LFQ screen drug 12, 473 N2102Ep α-ORF1p 4H1 - but this group probably doesn't have the mIgG control group.

Therefore, for this set: we have up to 4 replicates for 18 conditions and up to 8 replicates for 6 of those conditions - depending on if multi-well and screen can be mixed.

There is a google drive folder containing partial results from this work.


December 2020 - ROME screen_Hua

–> summary, includes link to RAW data

December 3, 2020 - N2102EP L1 screen in 24-well format

—> this is 24 samples in duplicate, including S-trapping

19/12/2020_LCMS sample queue: Hua's N2102EP L1 screen in 24-well format

DN> the above wiki entry is 1 uL injections, re-injected with 5 uL by LD

–> the LC-MS for this screen

Points

  • only need the 5ul runs
  • represents duplicates for each condition - can be combined with the data from manual screen? Can be combined with the data from 4x6 screen? Making up to 8 replicates for the experimental and 4 replicates for the controls
  • this data contains glutaraldehyde - keep? Discard?

December 2020 - ROME screen_Nastya

–> summary, includes link to RAW data (links?)

N2102EP 24-well Hand Screen 11-12-2020

–> this is 24 samples in duplicate

22/12/2020_S-Trap Micro Ulra High Recovery Updated Protocol (Nastya's IP buffer screening, part 1)

29/12/2020_S-Trap Micro Ulra High Recovery Updated Protocol (Nastya's IP buffer screening, part 2)

–> this is S-trapping for those.

23/12/2020_LCMS sample queue: Nasty's IP buffer screening part 1

29/12/2020_LCMS sample queue: Nasty's IP buffer screening part 2

DN> the above wiki entry is 1 uL injections, re-injected with 5 uL by LD

–> LC-MS for those


March 2, 2021 - N2102EP L1 screen in 24-well format (4x 6 conditions)

–> this is 4x6 in multi well format